Intramolecular regulation of presynaptic scaffold protein SYD-2/liprin-α
نویسندگان
چکیده
منابع مشابه
Intramolecular regulation of presynaptic scaffold protein SYD-2/liprin-α.
SYD-2/liprin-α is a multi-domain protein that associates with and recruits multiple active zone molecules to form presynaptic specializations. Given SYD-2's critical role in synapse formation, its synaptogenic ability is likely tightly regulated. However, mechanisms that regulate SYD-2 function are poorly understood. In this study, we provide evidence that SYD-2's function may be regulated by i...
متن کاملThe Liprin homology domain is essential for the homomeric interaction of SYD-2/Liprin-α protein in presynaptic assembly.
Synapses are asymmetric structures that are specialized for neuronal signal transduction. A unique set of proteins is present at the presynaptic active zone, which is a core structure essential for neurotransmitter release. In Caenorhabditis elegans HSN neurons, SYD-2, a Liprin-α family protein, acts together with a GAP protein SYD-1 to promote presynaptic assembly. Previous studies have shown ...
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ژورنال
عنوان ژورنال: Molecular and Cellular Neuroscience
سال: 2013
ISSN: 1044-7431
DOI: 10.1016/j.mcn.2013.03.004